CLEAR-HD: Cortical layer examination at high resolution in Huntington's disease

Purpose of the study


The purpose of this research study is to use novel high-resolution brain imaging techniques to assess whether subtle brain changes can be seen in Huntington's disease gene carriers who show no clinical signs of Huntington's and are completely well. This will allow us to guide the use of any potential future treatments, so that they can be given at the earliest and most effective time in order to prevent or treat Huntington's disease progression.


About the study


The CLEAR-HD study is an observational study using ultra-high resolution (or 7-Tesla) MRI and Magnetoencephalography (MEG). Both are safe and non-invasive techniques. The study aims to characterize how the structure and function of specific layers of the brain are affected in Huntington's disease and how these changes relate to abnormalities of deep brain structures.


What is involved? 


Following a screening phone call, eligible participants will be invited to a one-off visit, with the MEG scan in the morning, followed by clinical assessments and blood test, and MRI scan in the afternoon. 


Who can take part?


We are recruiting patients with pre-manifest, as well as those without the Huntington's disease gene, or those who are not from a Huntington's disease family between 18 and 65 years of age.


Read the participant information sheet


Get in touch


Chief Investigator: Dr Peter McColgan

Co-Investigator: Dr Mitsuko Nakajima

Email: [email protected]

Phone: (0) 203 108 7204